Flutemazepam

Flutemazepam[1][2] was developed at a team at Stabilimenti Chimici Farmaceutici Riuniti SpA in the mid 1970s. Is a drug which is a 3-hydroxy benzodiazepine derivative and an analogue of temazepam that has hypnotic, sedative, amnesiac, anxiolytic, anticonvulsant and skeletal muscle relaxant properties.[3] It is most closely related in structure to temazepam and is indicated for the treatment of severe sleep problem (insomnia).[4][5] Flutemazepam has properties similar to temazepam, and it has been found to be very effective for the treatment of severe states of anxiety, panic attacks, and severe insomnia.[6]

Flutemazepam
Clinical data
Pregnancy
category
  • X
Routes of
administration		Oral
ATC code
  • none
Legal status
Legal status
Identifiers
  • 7-chloro-5-(2-fluorophenyl)-3-hydroxy-1-methyl-3H-1,4-benzodiazepin-2-one
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
ECHA InfoCard100.052.612
Chemical and physical data
FormulaC16H12ClFN2O2
Molar mass318.730 g·mol−1
3D model (JSmol)
  • FC1=CC=CC=C1C2=NC(C(N(C)C3=C2C=C(C=C3)Cl)=O)O
  • InChI=1S/C16H12ClFN2O2/c1-20-13-7-6-9(17)8-11(13)14(19-15(21)16(20)22)10-4-2-3-5-12(10)18/h2-8,15,21H,1H3 Y
  • Key:RMFYWNFETXNTIQ-UHFFFAOYSA-N Y
 NY (what is this?)  (verify)

See also

References
  1. GB 1431282, "Benzodiazepine Compounds for Therapeutical Use", issued 7 April 1976, assigned to Schiapparelli Farma SpA
  2. PubChem. "Flutemazepam". pubchem.ncbi.nlm.nih.gov. Retrieved 2022-03-31.
  3. "Universal Guide for Temazepam". fastukmeds.com. Retrieved 2022-03-31.
  4. "Temazepam Oral: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing - WebMD". www.webmd.com. Retrieved 2022-03-31.
  5. "flutemazepam". psychotropics.dk. Retrieved 11 February 2009.
  6. Morton IK, Hall JM (1999). Concise Dictionary of Pharmacological Agents. Springer. ISBN 978-0-7514-0499-9.
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