Thatteem Mutteem

The recurring theme is the dispute between Mayavathyamma and her daughter-in-law Mohanavalli, and the struggle of the children and Arjunan to resolve it. Although the daughter-in-law has a strong dislike for the mother-in-law, they share mutual respect.

Arjunan's best friend, Kamalasanan, Mohanavalli's mother, Komalavalli, and Arjunan's sister, Kokila, pay them frequent visits, causing additional strife and drama in the family.

The whole family moves to a new home after having a dispute with the son of the owner of their previous home.

The daughter of the Arjunan' family, Meenakshi is now married to Aadhi Shankaran. Meenakshi found out that Aadhi is a lazy employee and is the son of Pravasi Shankaran, who is a poor NRI owed to many debts, but she kept this a secret and marries him believing that she can change him. She shows the same trait as her mother by having disputes with her mother-in-law, Vasavadatha, the wife of Pravasi Shankaran, who became mentally ill after winning a lottery which put ends to their debts. Despite their hateful relationship, the daughter-in-law and mother-in-law duo loved each other and shared mutual respect.

Meanwhile, Arjunan's millionaire brother Sahadevan, his wife Vidhubala, and his three children, Chinnu, Chikku and Chinnan, arrive from the United States. They are the owners of the house to which Mayavathi and her family belong.

Kannan, the only son of Mohanavalli and Arjunan falls in love with Rosamma, a Christian girl after a series of events that disapproved of the family. But later, for the dowry, they agree to their marriage to pay off a loan taken for Meenakshi's wedding, but the plan fails when Kannan unknowingly informs Rosamma's parents that he wants nothing from them except for their daughter. Meenakshi gives birth to triplets - Kunjumani, Muthumani and Kuttappayi and not so late after, she goes to the UK as a nurse to pay off the loan.

It shows the story, how life of Arjunan and family goes after the demise of Mayavathi amma.

• Manju Pillai as Mohanavalli: Homemaker mother of Meenakshi and Kannan, Arjunan's wife and Komalavalli's daughter.
• Jayakumar Parameswaran Pillai as Arjunan: A lazy government employee. Father of Meenakshi and Kannan and husband of Mohanavalli. He also portrays elder Krishnan Vakkeel, father of Arjunan, Sahadevan, Kokila, and Nakulan. Arjunan frequently writes underappreciated poems.
• Bhagyalakshmi Prabhu as Meenakshi: Daughter of Arjunan and Mohanavalli, Aadhi's wife, and Sahadevan's niece. She is a nurse in United Kingdom.
• Sidharth Prabhu as Kannan: Son of Arjunan and Mohanavalli, Sahadevan's nephew. He also portrays a young Krishnan Vakkeel & Teenager Arjunan.
• Sagar Surya as Aadhi Shankaran / Aadhi (Season 2): A lazy engineering post-graduate, husband of Meenakshi and the only son of Pravasi Shankaran and Vasavadattha.
• Naseer Sankranthi as Kamalasanan: A self-proclaimed politician. Arjunan's best friend and Sahadevan's classmate.
• Rajesh Paravoor as Sahadevan / Sahu (Season 2): Arjunan's younger brother, and father of Chikku, Chinnu, and Chinnan. He also portrayed the role of Doctor Parelal (Season 1 Ep:122).
• Shalu Kurian as Vidhubala / Vidhu (Season 2): Sahadevan's wife and Arjunan's younger sister-in-law, and mother of Chikku, Chinnu, and Chinnan.
• Parvathy Lal as Rosamma: Kannan's girlfriend.

• Veena Nair as Kokilakshi Shishupalan / Kokila: Arjunan's younger sister.
• Maneesha K. Subrahmaniam as Vasavadattha: Aadhi's mother and Shankaran's wife. She is a homemaker who won a lottery ticket.
• Nandakishor Nellickal as Pravasi Shankaran: Aadhi's father and Vasavadattha's insane husband.
• Anumol R. S as Chakki: Aadhi's cousin.
• Unni Nair as Ambooty, Vidhu's father. He is a traditional medicine practitioner & a Kalaripayattu expert.
• Arun G Arun as Chakkara / Chakkaraparambil Arun: Kannan's best friend.
• Malathi G. Menon as Subadhra, Krishnan Vakeel's ex client.
• Dhatri as Chinnu: Sahadevan's daughter, Chikku and Chinnan's sister.
• Aadhish Sudhakaran as Chikku: Sahadevan's elder son, Chinnu and Chinnan's brother.
• Vaishnav Menon as Chinnan: Sahadevan's younger son, Chinnu and Chikku's brother.
• Dhvani as Neenu: Meenakshi's best friend.
• Reshmi Anil as Meenkari Susheela. She plays lead role in a TV soap & she is also aunt of Rosamma.
• Vinod Kovoor as Doctor Moidu (Cameo)
• Meenakshi Raveendran as Nurse Kingini (Cameo)
• Sreelatha Namboothiri as Komalavalli: Mohanavalli's mother.
• Kochu Preman as Madhavan: Mayavathi's younger brother.
• Anitha Nair as Thankamani: Kamalasanan's breadwinner wife. She works as a helper in Anganwadi.
• Unknown as Bhavani: Kokila's daughter.
• Unknown as Bharathi: Kokila's daughter.
• Murugan as Shishubalan fondly called 'Shishu': Kokila's husband, Father of Bhavani & Bharati; Arjunan & Sahadevan's brother-in-law.
• Aleena Thankachan as Aparna, Thanima's younger sister and Kannan's ex fiancé.
• Anna Chacko as Thanima. She has mental health issues & she is obsessed with marrying Kannan.

• Kaviyoor Ponnamma as Herself, and Krishnan Vakkeel's co-star in a film (Season 1: Ep. 108)
• Vishnu Unnikrishnan as Himself (Season 2: Epi 189)
• Bibin George as Himself (Season 2: Epi 189)
• K. T. S. Padannayil as Mohanavalli's uncle (Season 1: Ep 276)
• Harisree Yousaf as Nakulan (season 1 episode 64)
• Promy as Subru
• Nitha Promy as Rukku
• Vivek Pillay as Richard Buttenhole
• Archana Menon as Adv. Kamala, Mohanavalli's friend (Season 1: Episode 306)
• Kavita as Mallika
• Mintu Maria Vincent as Mrunalini
• Sini Prasad as Annamma Chacko, Arjunan's strict, new boss, Executive Engineer (Season 2: 313,314)
• Sethu Lakshmi

• K. P. A. C. Lalitha as Mayavathi Amma: Mother of Arjunan, Sahadevan, Kokila, and Nakulan. She is the head of the family and the only breadwinner.
• Unknown as Pavanan: Arjunan's neighbour.
• Thushara Nambiar as Shakuntala: Pavanan's wife and a government hospital nurse.