Sarolaner

Sarolaner (brand name Simparica) is an ectoparasiticide veterinary drug for the treatment of flea and tick infestations in dogs.[1][2] It is also used off-label to control sarcoptic mange and demodectic mange.[2]

Sarolaner
Clinical data
Trade namesSimparica
Other namesPF-6450567
ATC code
  • None
Identifiers
  • 1-[6-[(5S)-5-(3,5-Dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4H-1,2-oxazol-3-yl]spiro[1H-2-benzofuran-3,3'-azetidine]-1'-yl]-2-methylsulfonylethanone
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
ECHA InfoCard100.234.000
Chemical and physical data
FormulaC23H18Cl2F4N2O5S
Molar mass581.36 g·mol−1
3D model (JSmol)
  • CS(=O)(=O)CC(=O)N1CC2(C1)OCc1cc(C3=NO[C@@](c4cc(Cl)c(F)c(Cl)c4)(C(F)(F)F)C3)ccc12
  • InChI=1S/C23H18Cl2F4N2O5S/c1-37(33,34)9-19(32)31-10-21(11-31)15-3-2-12(4-13(15)8-35-21)18-7-22(36-30-18,23(27,28)29)14-5-16(24)20(26)17(25)6-14/h2-6H,7-11H2,1H3/t22-/m0/s1
  • Key:FLEFKKUZMDEUIP-QFIPXVFZSA-N

Sarolaner is also a component of the combination drug Simparica Trio, which contains sarolaner, moxidectin, and pyrantel. It is used for prevention of heartworm disease caused by Dirofilaria immitis; treat and prevent flea infestations; treat and control tick infestations with the lone star tick, Gulf Coast tick, American dog tick, black-legged tick, and brown dog tick; and treat and control roundworm and adult hookworm infections.[3]

References
  1. McTier TL, Chubb N, Curtis MP, Hedges L, Inskeep GA, Knauer CS, et al. (May 2016). "Discovery of sarolaner: A novel, orally administered, broad-spectrum, isoxazoline ectoparasiticide for dogs" (PDF). Veterinary Parasitology. 222: 3–11. doi:10.1016/j.vetpar.2016.02.019. PMID 26961590.
  2. Gollakner R. "Sarolaner". vcahospitals.com. VCA Hospitals. Retrieved June 26, 2021.
  3. "FDA Approves Simparica Trio, a Combination Drug for Heartworm and Other Parasites". Food and Drug Administration. March 2, 2020. Retrieved June 26, 2021.
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