One Mindanao

Its main newscaster is Tek Ocampo, he started with Testigo (first named as Testigo: GMA Super Balita) on October 4, 1999 and made a name as a national reporter for GMA News when he left the show in 2002. After his stint with GMA Manila, he came back to Davao to anchor the program once more.

To strengthen the regional network's commitment of bringing the latest, most credible and most comprehensive news from the region, in February 2013, the newscast started its international broadcast on GMA News TV International alongside other regional newscasts Balitang Amianan and Balitang Bisdak.[4]

Testigo ended its 15-year run on November 7, 2014.

On November 10, 2014, the newscast adopts the branding of its now-main newscast 24 Oras as 24 Oras Southern Mindanao, following their change of graphics and theme music of the network's flagship newscast of the same name.

Since February 1, 2016, this program is the only GMA regional newscast to use the 24 Oras branding after two of its other regional newscasts reverted branding to its original names, Balitang Amianan (since 2008) and Balitang Bisdak (since 1999).

On October 3, 2016, 24 Oras Southern Mindanao changed once again its branding simply as 24 Oras Davao. The rebranding coincided to the 17th anniversary of the regional network's news department alongside GMA Cebu's Balitang Bisdak, as well as expanding out the coverage of GMA Dagupan's Balitang Amianan.[5]

On January 2, 2017, the newscast updated its opening billboard, soundtrack and lower third graphics similar to 24 Oras, together with other sister newscasts Balitang Amianan and Balitang Bisdak.

On April 17, 2017, senior correspondent Real Sorroche was promoted as anchor of the newscast, with the launch of his own segment Usapang Real.

With the end of 24 Oras Davao, GMA Regional TV launched a news program scoping the entire Mindanao island called One Mindanao. The newscast is also considered as the successor for other news programs produced by GMA for Mindanao, namely 24 Oras Northern Mindanao (formerly Testigo Northern Mindanao, from 2013 to 2015) of GMA Northern Mindanao and Soccksargen Isyu Karon (from 2010 to 2011) and Flash Bulletin (from 2010 to 2015) of GMA General Santos.[6] At the same time, GMA Cagayan de Oro reopened its studios with former relief anchor and correspondent Clyde Macascas (later replaced by Cyril Chaves, Ethel Ipanag and James Paolo Yap), which is used by the newscast. Prior to the launching of its studio, reports, and headlines from Cagayan de Oro City and the rest of Northern Mindanao and Caraga are aired live from the GMA Cagayan de Oro Control Room. From Soccsksargen, BARMM, and Zamboanga Peninsula (including Zamboanga City), reports and headlines are also brought by the newscast, the only used Cebuano and Filipino for the Mindanaoan-newscast from August 28, 2017 to November 22, 2019, now currently as switched full Cebuano language to the Mindanaoan-Newscast on November 25, 2019.

On July 29, 2019, the newscast unveiled a minor revision of its titlecard, changing its font color to green, reflecting it with its co-produced GMA Regional TV Weekend News (now Regional TV News), which was launched on July 27. One Mindanao was relaunched on August 19, 2019, adopting graphics and studio sets for Davao and Cagayan de Oro stations from the national newscast. In addition, the program opens its doors for viewers to become its live studio audience every Friday, similar to its sister regional newscast Balitang Bisdak.

Tek Ocampo left the newscast on September 24, 2021 to run for politics, while Real Sorroche was last seen anchoring the newscast due to unknown reasons, leaving Sarah Hilomen-Velasco as the remaining anchor of the newscast. She was then joined by correspondents Cyril Chaves, Jandi Esteban and Rgil Relator on September 27, 2021.

The program started using the studios from other provinces in the island, starting with the GMA Zamboanga Station on March 22, 2022 and GMA General Santos Station on May 2, 2022, which have been recently opened since then. News producers and co-anchors Efren Mamac from GMA Zamboanga and Jestoni Jumamil from GMA General Santos were added to the newscast.