LPAR5

LPAR5
Identifiers
Aliases	LPAR5, GPR92, GPR93, KPG_010, LPA5, lysophosphatidic acid receptor 5
External IDs	OMIM: 606926 MGI: 2685918 HomoloGene: 10696 GeneCards: LPAR5
Gene location (Human)
Chr.	Chromosome 12 (human)[1]
End	6,635,960 bp[1]
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)[2]
End	125,059,435 bp[2]
RNA expression pattern
	Top expressed in
	vagina; ; synovial membrane; ; cavity of mouth; ; thymus;
	More reference expression data
	n/a
Gene ontology
Molecular function	G protein-coupled receptor activity; signal transducer activity; molecular function;
Cellular component	integral component of membrane; plasma membrane; membrane; cellular component;
Biological process	signal transduction; G protein-coupled receptor signaling pathway; biological process; positive regulation of CREB transcription factor activity; behavioral response to pain;
	Sources:Amigo / QuickGO
Orthologs
	57121
	381810
	ENSG00000184574
	ENSMUSG00000067714
	Q9H1C0
	Q149R9
	NM_020400; NM_001142961
	NM_001163268; NM_001163269
	NP_001136433; NP_065133
	NP_001156740; NP_001156741
	Wikidata
View/Edit Human	View/Edit Mouse

Lysophosphatidic acid receptor 5 also known as LPA₅ is a protein that in humans is encoded by the LPAR5 gene.[5][6][7][8][9] LPA₅ is a G protein-coupled receptor that binds the lipid signaling molecule lysophosphatidic acid (LPA).[10]

References

GRCh38: Ensembl release 89: ENSG00000184574 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000067714 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
White, Kenneth E.; Evans, Wayne E.; O'Riordan, Jeffery L.H.; Speer, Marcy C.; Econs, Michael J.; Lorenz-Depiereux, Bettina; Grabowski, Monika; Meitinger, Thomas; Strom, Tim M. (Dec 2000). "Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23". Nat Genet. 26 (3): 345–8. doi:10.1038/81664. PMID 11062477. S2CID 38870810.
Lee DK, Nguyen T, Lynch KR, Cheng R, Vanti WB, Arkhitko O, Lewis T, Evans JF, George SR, O'Dowd BF (Sep 2001). "Discovery and mapping of ten novel G protein-coupled receptor genes". Gene. 275 (1): 83–91. doi:10.1016/S0378-1119(01)00651-5. PMID 11574155.
Lee CW, Rivera R, Gardell S, Dubin AE, Chun J (Aug 2006). "GPR92 as a new G12/13- and Gq-coupled lysophosphatidic acid receptor that increases cAMP, LPA5". J Biol Chem. 281 (33): 23589–97. doi:10.1074/jbc.M603670200. PMID 16774927.
Kotarsky K, Boketoft A, Bristulf J, Nilsson NE, Norberg A, Hansson S, Owman C, Sillard R, Leeb-Lundberg LM, Olde B (Jul 2006). "Lysophosphatidic acid binds to and activates GPR92, a G protein-coupled receptor highly expressed in gastrointestinal lymphocytes". J Pharmacol Exp Ther. 318 (2): 619–28. doi:10.1124/jpet.105.098848. PMID 16651401. S2CID 5989815.
"Entrez Gene: GPR92 G protein-coupled receptor 92".
Choi JW, Herr DR, Noguchi K, Yung YC, Lee CW, Mutoh T, Lin ME, Teo ST, Park KE, Mosley AN, Chun J (January 2010). "LPA Receptors: Subtypes and Biological Actions". Annual Review of Pharmacology and Toxicology. 50 (1): 157–186. doi:10.1146/annurev.pharmtox.010909.105753. PMID 20055701.

LPAR5

See also

References

Further reading