Allithiamine

Allithiamine (thiamine allyl disulfide or TAD) is a lipid-soluble form of vitamin B1 which was discovered in garlic (Allium sativum) in the 1950s along with its homolog prosultiamine.[1] They were both investigated for their ability to treat Wernicke–Korsakoff syndrome and beriberi better than thiamine.[2]

Allithiamine
Clinical data
ATC code
  • None
Identifiers
  • N-[(4-Amino-2-methylpyrimidin-5-yl)methyl]-N-[(1Z)-4-hydroxy-1-methyl-2-(prop-2-en-1-yldisulfanyl)but-1-en-1-yl]formamide
CAS Number
PubChem CID
ChemSpider
UNII
Chemical and physical data
FormulaC15H22N4O2S2
Molar mass354.49 g·mol−1
3D model (JSmol)
  • O=CN(/C(=C(\SSC\C=C)CCO)C)Cc1cnc(nc1N)C
  • InChI=1S/C15H22N4O2S2/c1-4-7-22-23-14(5-6-20)11(2)19(10-21)9-13-8-17-12(3)18-15(13)16/h4,8,10,20H,1,5-7,9H2,2-3H3,(H2,16,17,18)/b14-11- Y
  • Key:WNCAVNGLACHSRZ-KAMYIIQDSA-N Y
 NY (what is this?)  (verify)

See also

References
  1. Fujiwara M, Watanabe H, Matsui K (1954). ""Allithiamine" A Newly Found Derivative of Vitamin B1". The Journal of Biochemistry. 41: 29–39. doi:10.1093/oxfordjournals.jbchem.a126421.
  2. Rogers EF (April 1962). "Thiamine antagonists". Annals of the New York Academy of Sciences. 98 (2): 412–29. Bibcode:1962NYASA..98..412R. doi:10.1111/j.1749-6632.1962.tb30563.x. PMID 14493332. S2CID 32281714.
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.