Sumatriptan/naproxen sodium

Sumatriptan/naproxen sodium, sold under the brand name Treximet, is a combination medication used to treat migraines attacks.[1] It is taken through oral route.[1]

Sumatriptan/naproxen sodium
Combination of
SumatriptanTriptan
Naproxen sodiumNSAID
Clinical data
Trade namesTreximet, Trexima, others
Routes of
administration		By mouth
Identifiers
CAS Number
KEGG

Active ingredients

It combines 85 mg of sumatriptan, a selective 5-hydroxytryptamine1 (5-HT1) receptor subtype agonist and 500 mg of naproxen sodium, a member of the arylacetic acid group of nonsteroidal anti-inflammatory drugs (NSAIDs), in one tablet.

Medical use

A Cochrane review in 2020 found that the combination of sumatriptan plus naproxen was better than placebo for relieving acute migraine attacks in adults. When the starting headache intensity was mild, 5 in 10 (50%) of people treated with the combination were pain-free at two hours compared with about 2 in 10 (18%) with placebo. Almost 6 in 10 (58%) people with moderate or severe pain who were treated with the combination had pain reduced to mild or none at two hours, compared with 3 in 10 (27%) with placebo. The combination was also better than the same dose of either drug given alone in these people. Results were 5 in 10 (52%) people with sumatriptan alone or about 4 in 10 (44%) with naproxen alone.[2]

Side effects

Some of the listed side effects include dizziness, nausea, sleepiness, dry mouth, pain in neck, throat or jaw, numbness or tingling.[3]

References
  1. "DailyMed - sumatriptan succinate and naproxen sodium tablet, film coated". dailymed.nlm.nih.gov. Retrieved 6 March 2019.
  2. Law S, Derry S, Moore RA (April 2016). "Sumatriptan plus naproxen for the treatment of acute migraine attacks in adults". The Cochrane Database of Systematic Reviews. 4 (4): CD008541. doi:10.1002/14651858.CD008541.pub3. PMC 6485397. PMID 27096438.
  3. "Treximet". Drugs.com.
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