Phosphogluconate dehydratase
In enzymology, a phosphogluconate dehydratase (EC 4.2.1.12) is an enzyme that catalyzes the chemical reaction
- 6-phospho-D-gluconate 2-dehydro-3-deoxy-6-phospho-D-gluconate + H2O
| phosphogluconate dehydratase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 6-Phosphogluconate dehydratase monomer, Shewanella oneidensis | |||||||||
| Identifiers | |||||||||
| EC no. | 4.2.1.12 | ||||||||
| CAS no. | 9024-33-3 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Hence, this enzyme has one substrate, 6-phospho-D-gluconate, and two products, 2-dehydro-3-deoxy-6-phospho-D-gluconate and H2O.
This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is 6-phospho-D-gluconate hydro-lyase (2-dehydro-3-deoxy-6-phospho-D-gluconate-forming). Other names in common use include 6-phosphogluconate dehydratase, 6-phosphogluconic dehydrase, gluconate-6-phosphate dehydratase, gluconate 6-phosphate dehydratase, 6-phosphogluconate dehydrase, and 6-phospho-D-gluconate hydro-lyase. This enzyme participates in Entner–Doudoroff pathway.
Structural studies
As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2GP4.
References
- MELOCHE HP, WOOD WA (1964). "The Mechanism of 6-Phosphogluconic Dehydrase". J. Biol. Chem. 239: 3505–10. PMID 14245409.