Antonios Mikos

Antonios Georgios Mikos (born 1960)[1] is a Greek-American biomedical engineer who is the Louis Calder Professor of Bioengineering and Chemical and Biomolecular Engineering at Rice University.[2][3] He is a pioneer in the fields of biomaterials, drug delivery, and tissue engineering.[4][5]

Antonios G. Mikos
BornDecember 30, 1960
Thessaloniki, Greece
Alma materAristotle University of Thessaloniki, Purdue University
Known forBiomaterials science
AwardsActa Biomaterialia Gold Medal (2019), Lifetime Achievement Award, Tissue Engineering and Regenerative Medicine International Society-Americas (2015), Founders Award, Society For Biomaterials (2011), Robert A. Pritzker Distinguished Lecturer Award, Biomedical Engineering Society (2007)
Scientific career
FieldsBioengineering, Chemical and Biomolecular Engineering
InstitutionsRice University
Doctoral advisorNicholas A. Peppas
Other academic advisorsRobert S. Langer, Joseph P. Vacanti
Websitehttp://mikoslab.rice.edu/

Education

Mikos completed undergraduate study in engineering at the Aristotle University of Thessaloniki (Dipl. Eng., 1983), and pursued a master's and doctorate (M.S. in chemical engineering, 1985 and Ph.D. in chemical engineering, 1988) at Purdue University in the United States.[6][5] After his doctoral studies, he performed his postdoctoral work at Massachusetts Institute of Technology and the Harvard Medical School.[6][4][5]

Career

Mikos is the Louis Calder Professor of Bioengineering and Chemical and Biomolecular Engineering at Rice University in Houston, Texas.[4][5] He is also the Director of the National Institutes of Health Center for Engineering Complex Tissues, Director of the Center for Excellence in Tissue Engineering, and Director of the John W. Cox Laboratory of Biomedical Engineering at Rice University.[4][5]

Mikos’ research centers on developing innovative biomaterial systems that can be leveraged for tissue engineering, drug delivery, gene delivery, and disease modeling applications.[4][5][7] His expertise has resulted in advancements in scaffolds for cartilage,[8] bone,[9] muscle,[10][11][12] and cardiovascular[13] engineering, controlled release platforms for growth factors,[14] non-viral vectors,[15] and scaffolds for studying tumor microenvironments.[16] Specifically, current research in his lab aims to develop 3D printing strategies including extracellular matrix and nanoparticle-based bioinks for osteochondral tissue engineering,[17] to evaluate injectable bio-inspired thermoresponsive hydrogel systems for bone and cartilage regeneration,[18][19] and to enable tissue engineering strategies including mechanically modular electrospun scaffolds for modeling tumor microenvironments.[16][20]

Mikos has contributed to more than 680 publications and 32 patents.[4][5] He has also co-authored a textbook entitled Biomaterials: The Intersection of Biology and Materials Science (Pearson, 1st Ed. (2008) and 2nd Ed. (2023)).[4][5][21] As of March 2022, his publications have more than 89,000 citations, and he has an H-index of 154.[4][5][22]

Mikos has been elected as a member of the National Academy of Engineering (2012),[23] the National Academy of Medicine (2012),[24] the Academy of Medicine, Engineering and Science of Texas (2012),[25] the National Academy of Inventors (2014),[26] the Academy of Athens (2016),[1] the International Academy of Medical and Biological Engineering (2017),[27] the Academia Europaea (2020),[28] and the Chinese Academy of Engineering (2021).[29][4][5][30]

Mikos has also been elected as a Fellow of the American Institute for Medical and Biological Engineering (1999), a Fellow of the International Union of Societies for Biomaterials Science and Engineering (2000), a Fellow of the Biomedical Engineering Society (2009), a Fellow of the Controlled Release Society (2011), a Fellow of the American Association for the Advancement of Science (2012), a Founding Fellow of the Tissue Engineering and Regenerative Medicine International Society (2012), and Fellow of the American Institute of Chemical Engineers (2014).[4][5]

Mikos founded the journals Tissue Engineering Part A, Tissue Engineering Part B: Review, and Tissue Engineering Part C: Methods and currently serves as their editor-in-chief.[4][5][31] He also serves on the editorial boards of multiple other journals including Advanced Drug Delivery Reviews,[32] Cell Transplantation,[33] Journal of Biomaterials Science Polymer Edition,[34] Journal of Biomedical Materials Research (Part A and B),[35] and Journal of Controlled Release[36].[4][5] He has offered an annual educational short course (Advances in Tissue Engineering) that covers various topics related to the field of tissue engineering at Rice University since 1993.[4][5][37]

Mikos served as past President of the Tissue Engineering and Regenerative Medicine International Society-Americas and the Society For Biomaterials.[4][5][38][39]

Awards
  • Elected to the National Academy of Engineering (2012)[23]
  • Elected to the National Academy of Medicine (2012)[24]
  • Elected to the Academy of Medicine, Engineering and Science of Texas (2012)[25]
  • Elected to the National Academy of Inventors (2014)[26]
  • Elected to the Academy of Athens (2016)[1]
  • Elected to the International Academy of Medical and Biological Engineering (2017)[27]
  • Elected to the Academia Europaea (2020)[28]
  • Elected to the Chinese Academy of Engineering (2021)[29]
  • Presidential Mentoring Award, Rice University (2022)[4][5][30]

References
  1. "Members of the First Section". Academy of Athens. Retrieved 2022-02-03.
  2. "Antonios Mikos". rice.edu. Retrieved May 3, 2017.
  3. "Antonios Mikos". rice.edu. Retrieved May 3, 2017.
  4. "Mikos Lab - Principal Investigator". mikoslab.rice.edu. Retrieved 2022-03-29.
  5. "Antonios Mikos Rice University Profile". Retrieved March 28, 2022.
  6. "Antonios G. Mikos". Purdue University College of Engineering. 2014. Retrieved 29 October 2019.
  7. "Mikos Lab - Home". mikoslab.rice.edu. Retrieved 2022-03-29.
  8. Kim, Yu Seon; Mehta, Shail M.; Guo, Jason L.; Pearce, Hannah A.; Smith, Brandon T.; Watson, Emma; Koons, Gerry L.; Navara, Adam M.; Lam, Johnny; Grande‐Allen, K. Jane; Mikos, Antonios G. (2021-05-11). "Evaluation of tissue integration of injectable, cell‐laden hydrogels of cocultures of mesenchymal stem cells and articular chondrocytes with an ex vivo cartilage explant model". Biotechnology and Bioengineering. 118 (8): 2958–2966. doi:10.1002/bit.27804. ISSN 0006-3592.
  9. Watson, Emma; Tatara, Alexander M.; van den Beucken, Jeroen J.J.P.; Jansen, John A.; Wong, Mark E.; Mikos, Antonios G. (2020-07-01). "An Ovine Model of In Vivo Bioreactor-Based Bone Generation". Tissue Engineering Part C: Methods. 26 (7): 384–396. doi:10.1089/ten.tec.2020.0125. ISSN 1937-3384. PMC 7398437. PMID 32536266.
  10. Smoak, Mollie M.; Han, Albert; Watson, Emma; Kishan, Alysha; Grande-Allen, K. Jane; Cosgriff-Hernandez, Elizabeth; Mikos, Antonios G. (2019-05-01). "Fabrication and Characterization of Electrospun Decellularized Muscle-Derived Scaffolds". Tissue Engineering Part C: Methods. 25 (5): 276–287. doi:10.1089/ten.tec.2018.0339. ISSN 1937-3384. PMC 6535957. PMID 30909819.
  11. Smoak, Mollie M.; Hogan, Katie J.; Grande-Allen, K. Jane; Mikos, Antonios G. (2021-05-14). "Bioinspired electrospun dECM scaffolds guide cell growth and control the formation of myotubes". Science Advances. 7 (20): eabg4123. doi:10.1126/sciadv.abg4123. ISSN 2375-2548. PMC 8121426. PMID 33990336.
  12. Hogan, Katie J.; Smoak, Mollie M.; Koons, Gerry L.; Perez, Marissa R.; Bedell, Matthew L.; Jiang, Emily Y.; Young, Simon; Mikos, Antonios G. (2022-01-06). "Bioinspired electrospun decellularized extracellular matrix scaffolds promote muscle regeneration in a rat skeletal muscle defect model". Journal of Biomedical Materials Research Part A. 110 (5): 1090–1100. doi:10.1002/jbm.a.37355. ISSN 1549-3296.
  13. Suggs, Laura J.; Mikos, Antonios G. (July 1999). "Development of Poly(Propylene Fumarate-co-Ethylene Glycol) as an Injectable Carrier for Endothelial Cells". Cell Transplantation. 8 (4): 345–350. doi:10.1177/096368979900800402. ISSN 0963-6897.
  14. Habraken, W. J. E. M.; Boerman, O. C.; Wolke, J. G. C.; Mikos, A. G.; Jansen, J. A. (November 2009). "In vitro growth factor release from injectable calcium phosphate cements containing gelatin microspheres". Journal of Biomedical Materials Research Part A. 91A (2): 614–622. doi:10.1002/jbm.a.32263.
  15. Needham, Clark J.; Williams, Austin K.; Chew, Sue Anne; Kasper, F. Kurtis; Mikos, Antonios G. (2012-05-14). "Engineering a Polymeric Gene Delivery Vector Based on Poly(ethylenimine) and Hyaluronic Acid". Biomacromolecules. 13 (5): 1429–1437. doi:10.1021/bm300145q. ISSN 1525-7797. PMC 3351541. PMID 22455481.
  16. Molina, Eric R.; Chim, Letitia K.; Salazar, Maria C.; Koons, Gerry L.; Menegaz, Brian A.; Ruiz-Velasco, Alejandra; Lamhamedi-Cherradi, Salah-Eddine; Vetter, Amelia M.; Satish, Tejus; Cuglievan, Branko; Smoak, Mollie M. (2020-01-13). "3D Tissue-Engineered Tumor Model for Ewing's Sarcoma That Incorporates Bone-like ECM and Mineralization". ACS Biomaterials Science & Engineering. 6 (1): 539–552. doi:10.1021/acsbiomaterials.9b01068.
  17. Navara, Adam M.; Kim, Yu Seon; Xu, Yilan; Crafton, Christopher L.; Diba, Mani; Guo, Jason L.; Mikos, Antonios G. (2022-08-01). "A dual-gelling poly(N-isopropylacrylamide)-based ink and thermoreversible poloxamer support bath for high-resolution bioprinting". Bioactive Materials. 14: 302–312. doi:10.1016/j.bioactmat.2021.11.016. ISSN 2452-199X. PMC 8897628. PMID 35310364.
  18. Guo, J. L.; Kim, Y. S.; Xie, V. Y.; Smith, B. T.; Watson, E.; Lam, J.; Pearce, H. A.; Engel, P. S.; Mikos, A. G. (2019-06-07). "Modular, tissue-specific, and biodegradable hydrogel cross-linkers for tissue engineering". Science Advances. 5 (6). doi:10.1126/sciadv.aaw7396. ISSN 2375-2548. PMC 6551165. PMID 31183408.
  19. Guo, Jason L.; Li, Ang; Kim, Yu Seon; Xie, Virginia Y.; Smith, Brandon T.; Watson, Emma; Bao, Gang; Mikos, Antonios G. (2019-12-13). "Click functionalized, tissue‐specific hydrogels for osteochondral tissue engineering". Journal of Biomedical Materials Research Part A. 108 (3): 684–693. doi:10.1002/jbm.a.36848. ISSN 1549-3296. PMC 7942178. PMID 31755226.
  20. Molina, Eric R.; Chim, Letitia K.; Salazar, Maria C.; Mehta, Shail M.; Menegaz, Brian A.; Lamhamedi-Cherradi, Salah-Eddine; Satish, Tejus; Mohiuddin, Sana; McCall, David; Zaske, Ana Maria; Cuglievan, Branko (2019-12-01). "Mechanically tunable coaxial electrospun models of YAP/TAZ mechanoresponse and IGF-1R activation in osteosarcoma". Acta Biomaterialia. 100: 38–51. doi:10.1016/j.actbio.2019.09.029. ISSN 1742-7061. PMC 7027943. PMID 31542501.
  21. "Biomaterials: The Intersection of Biology and Materials Science". www.pearson.com. Retrieved 2022-03-29.
  22. "Antonios G. Mikos Citations H-Index". scholar.google.com. Retrieved 2022-03-29.
  23. "Dr. Antonios Georgios Mikos". National Academy of Engineering. Retrieved 29 October 2019.
  24. "Antonios Mikos NAM Member". National Academy of Medicine. Retrieved 2022-03-29.
  25. "Members - TAMEST (The Academy of Medicine, Engineering and Science of Texas)". TAMEST The Academy of Medicine, Engineering and Science of Texas. Retrieved 2022-03-29.
  26. "National Academy of Inventors". Retrieved 2022-03-29.
  27. "IAMBE". www.iambe-ifmbe.org. Retrieved 2022-03-29.
  28. "Academy of Europe: Mikos Antonios". www.ae-info.org. Retrieved 2022-03-29.
  29. "Chinese Academy of Engineering". en.cae.cn. Retrieved 2022-03-29.
  30. "Honors and Awards – Dr. Mikos «". mikoslab.rice.edu. Retrieved 2022-03-29.
  31. "Tissue Engineering, Parts A, B, & C | Mary Ann Liebert, Inc., publishers". home.liebertpub.com. Retrieved 2022-03-29.
  32. "Editorial Board - Advanced Drug Delivery Reviews - Journal - Elsevier". www.journals.elsevier.com. Retrieved 2022-03-29.
  33. "Cell Transplantation Editorial Board". Retrieved March 28, 2022.
  34. "Journal of Biomaterials Science, Polymer Edition Editorial Board". www.tandfonline.com. Retrieved 2022-03-29.
  35. "Journal of Biomedical Materials Research Part B: Applied Biomaterials". Wiley Online Library. Retrieved 2022-03-29.
  36. "Editorial Board - Journal of Controlled Release - Journal - Elsevier". www.journals.elsevier.com. Retrieved 2022-03-29.
  37. "Advances in Tissue Engineering Short Course". tissue.rice.edu. Retrieved 2022-03-29.
  38. "Past Governing Board Members | TERMIS". termis.org. Retrieved 2022-03-29.
  39. "Past Presidents | Society for Biomaterials (SFB)". biomaterials.org. Retrieved 2022-03-29.
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