LGSN

Lengsin is a protein that in humans is encoded by the LGSN gene.

LGSN
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2J9I
Identifiers
Aliases	LGSN, GLULD1, LGS, lengsin, lens protein with glutamine synthetase domain
External IDs	OMIM: 611470 MGI: 2672844 HomoloGene: 9569 GeneCards: LGSN
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q12 Start 63,275,951 bp[1] End 63,319,983 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 B Start 31,215,482 bp[2] End 31,243,806 bp[2]
RNA expression pattern Bgee Top expressed in liver Right lobe of liver kidney substantia nigra blood visceral pleura More reference expression data BioGPS n/a
Gene ontology Molecular function catalytic activity glutamate-ammonia ligase activity Cellular component plasma membrane membrane Biological process glutamine biosynthetic process nitrogen compound metabolic process nitrogen utilization Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	51557	266744
Ensembl	ENSG00000146166	ENSMUSG00000050217
UniProt	Q5TDP6	Q8CIX8
RefSeq (mRNA)	NM_001143940 NM_016571	NM_153601
RefSeq (protein)	NP_001137412 NP_057655	NP_705829
Location (UCSC)	Chr 6: 63.28 – 63.32 Mb	Chr 1: 31.22 – 31.24 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Lengsin is a survivor of an ancient family of class I glutamine synthetases in eukaryotes that has undergone evolutionary re-engineering for a tissue-specific, noncatalytic role in the lens of the vertebrate eye.[5] Lengsin is the result of the recruitment of an ancient enzyme may act as a component of the cytoskeleton or as a chaperone for the reorganization of intermediate filament proteins during terminal differentiation in the lens. It does not seem to have enzymatic activity.