Krista Varady

Krista A. Varady is a Canadian-American scientist known for her studies of intermittent fasting on chronic disease risk in human subjects.[1][2][3][4][5][6][7][8] Varady was one of the first scientists to study intermittent fasting in humans.[4] She is currently a professor of nutrition at the University of Illinois Chicago (UIC) in the department of Kinesiology and Nutrition.[9] She also serves as the director of the Human Nutrition Research Center at UIC.[9] Her work is primarily funded by the National Institutes of Health.[10] She is also the author of a book about intermittent fasting for the general public, titled The Every Other Day Diet.[11]

Krista Varady, PhD

Education

Varady completed her Bachelor's degree in dietetics at the University of Guelph.[9] She then attended McGill University, where she completed her PhD in human nutrition. Her PhD dissertation examined the effects of plant sterols combined with exercise on cholesterol metabolism.[12] After her PhD, she joined the laboratory of Mark Hellerstein at the University of California, Berkeley, to study the health benefits of intermittent fasting.[9] While at Berkeley, she published several pioneering animal studies in this area,[13][14][15] and the first literature review of intermittent fasting.[16]

Studies of alternate day fasting

Varady has published numerous seminal articles examining how alternate day fasting impacts human health. In 2017, her lab published the first long-term (12-month) human trial of fasting.[17] This study showed that alternate day fasting is just as effective as traditional dieting, i.e daily calorie restriction, for weight loss and weight maintenance.[17] Her lab has also published several key studies demonstrating that intermittent fasting is a safe diet therapy [18] that can be used to lower cholesterol levels, blood pressure, and improve glycemic control in individuals with obesity and pre-diabetes.[19][20][21][22][23] Furthermore, she has shown that alternate day fasting can be safely combined with exercise to improve body composition.[21]

Studies of time restricted eating

In 2018, she began studying the health effects of time restricted eating. Her trials have demonstrated that eating within 4-hour,[24] 6-hour,[24] or 8-hour[25] window each day is safe [26] and effective for lowering body weight, reducing blood pressure, insulin resistance, and oxidative stress in adults with obesity. Varady's lab was the first to show that time restricted eating results in energy restriction (by about 300-600 calories per day), without calorie counting.[24][25] She has also published several notable review articles [27][28][29][30] summarizing the emerging benefits of time restricted eating.

Honors

In 2017 she received the Mead Johnson Young Investigator Award from the American Society for Nutrition for her work in intermittent fasting.[31][32]

References
  1. Bakalar, Nicholas (2020-07-27). "Intermittent Fasting May Aid Weight Loss". The New York Times. ISSN 0362-4331. Retrieved 2022-03-29.
  2. O’Connor, Anahad (2020-09-28). "A Potential Downside of Intermittent Fasting". The New York Times. ISSN 0362-4331. Retrieved 2022-03-29.
  3. Martin, Crystal (2019-11-23). "What Is Intermittent Fasting and Does It Really Work?". The New York Times. ISSN 0362-4331. Retrieved 2022-03-29.
  4. Hamblin, James (2014-01-23). "The New Way to Love Food". The Atlantic. Retrieved 2022-03-29.
  5. Wallis, Claudia (2020-09-01). "How Good a Diet Is Intermittent Fasting?". Scientific American.
  6. "Intermittent fasting and why when you eat makes a difference". Washington Post. ISSN 0190-8286. Retrieved 2022-03-29.
  7. "In a 24/7 food culture, periodic fasting gains followers". AP NEWS. Retrieved 2022-03-29.
  8. Reddy, Sumathi (2017-12-31). "A Diet Strategy That Counts Time, Not Calories". Wall Street Journal. ISSN 0099-9660. Retrieved 2022-03-29.
  9. "Krista Varady". ahs.uic.edu. Retrieved 2022-03-29.
  10. "RePORT ⟩ RePORTER". reporter.nih.gov. Retrieved 2022-03-29.
  11. Varady, Krista; Gottlieb, Bill (2013). The Every Other Day Diet. New York, NY: Hyperion. ISBN 978-0-316-33058-9. OCLC 865473722.
  12. Varady, Krista A; Ebine, Naoyuki; Vanstone, Catherine A; Parsons, William E; Jones, Peter JH (2004-11-01). "Plant sterols and endurance training combine to favorably alter plasma lipid profiles in previously sedentary hypercholesterolemic adults after 8 wk". The American Journal of Clinical Nutrition. 80 (5): 1159–1166. doi:10.1093/ajcn/80.5.1159. ISSN 0002-9165. PMID 15531661.
  13. Varady, K.A.; Roohk, D.J.; Loe, Y.C.; McEvoy-Hein, B.K.; Hellerstein, M.K. (October 2007). "Effects of modified alternate-day fasting regimens on adipocyte size, triglyceride metabolism, and plasma adiponectin levels in mice". Journal of Lipid Research. 48 (10): 2212–2219. doi:10.1194/jlr.M700223-JLR200. PMID 17607017. S2CID 16068865.
  14. Varady, K. A.; Roohk, D. J.; McEvoy‐Hein, B. K.; Gaylinn, B. D.; Thorner, M. O.; Hellerstein, M. K. (June 2008). "Modified alternate‐day fasting regimens reduce cell proliferation rates to a similar extent as daily calorie restriction in mice". The FASEB Journal. 22 (6): 2090–2096. doi:10.1096/fj.07-098178. ISSN 0892-6638. PMC 2975447. PMID 18184721.
  15. Varady, Krista A.; Allister, Candice A.; Roohk, Donald J.; Hellerstein, Marc K. (March 2010). "Improvements in body fat distribution and circulating adiponectin by alternate-day fasting versus calorie restriction☆". The Journal of Nutritional Biochemistry. 21 (3): 188–195. doi:10.1016/j.jnutbio.2008.11.001. PMID 19195863.
  16. Varady, Krista A; Hellerstein, Marc K (2007-07-01). "Alternate-day fasting and chronic disease prevention: a review of human and animal trials". The American Journal of Clinical Nutrition. 86 (1): 7–13. doi:10.1093/ajcn/86.1.7. ISSN 0002-9165. PMID 17616757.
  17. Trepanowski, John F.; Kroeger, Cynthia M.; Barnosky, Adrienne; Klempel, Monica C.; Bhutani, Surabhi; Hoddy, Kristin K.; Gabel, Kelsey; Freels, Sally; Rigdon, Joseph; Rood, Jennifer; Ravussin, Eric (2017-07-01). "Effect of Alternate-Day Fasting on Weight Loss, Weight Maintenance, and Cardioprotection Among Metabolically Healthy Obese Adults: A Randomized Clinical Trial". JAMA Internal Medicine. 177 (7): 930–938. doi:10.1001/jamainternmed.2017.0936. ISSN 2168-6106. PMC 5680777. PMID 28459931.
  18. Hoddy, Kristin K; Kroeger, Cynthia M; Trepanowski, John F; Barnosky, Adrienne R; Bhutani, Surabhi; Varady, Krista A (December 2015). "Safety of alternate day fasting and effect on disordered eating behaviors". Nutrition Journal. 14 (1): 44. doi:10.1186/s12937-015-0029-9. ISSN 1475-2891. PMC 4424827. PMID 25943396.
  19. Varady, Krista A; Bhutani, Surabhi; Church, Emily C; Klempel, Monica C (2009-11-01). "Short-term modified alternate-day fasting: a novel dietary strategy for weight loss and cardioprotection in obese adults". The American Journal of Clinical Nutrition. 90 (5): 1138–1143. doi:10.3945/ajcn.2009.28380. ISSN 0002-9165. PMID 19793855.
  20. Varady, Krista A; Bhutani, Surabhi; Klempel, Monica C; Kroeger, Cynthia M; Trepanowski, John F; Haus, Jacob M; Hoddy, Kristin K; Calvo, Yolian (December 2013). "Alternate day fasting for weight loss in normal weight and overweight subjects: a randomized controlled trial". Nutrition Journal. 12 (1): 146. doi:10.1186/1475-2891-12-146. ISSN 1475-2891. PMC 3833266. PMID 24215592.
  21. Bhutani, Surabhi; Klempel, Monica C.; Kroeger, Cynthia M.; Trepanowski, John F.; Varady, Krista A. (July 2013). "Alternate day fasting and endurance exercise combine to reduce body weight and favorably alter plasma lipids in obese humans: Alternate Day Fasting and Exercise for Weight Loss". Obesity. 21 (7): 1370–1379. doi:10.1002/oby.20353. PMID 23408502. S2CID 264329.
  22. Gabel, Kelsey; Kroeger, Cynthia M.; Trepanowski, John F.; Hoddy, Kristin K.; Cienfuegos, Sofia; Kalam, Faiza; Varady, Krista A. (2019-07-22). "Differential Effects of Alternate‐Day Fasting Versus Daily Calorie Restriction on Insulin Resistance". Obesity. 27 (9): 1443–1450. doi:10.1002/oby.22564. ISSN 1930-7381. PMC 7138754. PMID 31328895.
  23. Hoddy, Kristin K.; Kroeger, Cynthia M.; Trepanowski, John F.; Barnosky, Adrienne; Bhutani, Surabhi; Varady, Krista A. (December 2014). "Meal timing during alternate day fasting: Impact on body weight and cardiovascular disease risk in obese adults: Meal Timing During Alternate Day Fasting". Obesity. 22 (12): 2524–2531. doi:10.1002/oby.20909. PMID 25251676. S2CID 25459457.
  24. Cienfuegos, Sofia; Gabel, Kelsey; Kalam, Faiza; Ezpeleta, Mark; Wiseman, Eric; Pavlou, Vasiliki; Lin, Shuhao; Oliveira, Manoela Lima; Varady, Krista A. (September 2020). "Effects of 4- and 6-h Time-Restricted Feeding on Weight and Cardiometabolic Health: A Randomized Controlled Trial in Adults with Obesity". Cell Metabolism. 32 (3): 366–378.e3. doi:10.1016/j.cmet.2020.06.018. PMID 32673591. S2CID 220609271.
  25. Gabel, Kelsey; Hoddy, Kristin K.; Haggerty, Nicole; Song, Jeehee; Kroeger, Cynthia M.; Trepanowski, John F.; Panda, Satchidananda; Varady, Krista A. (2018-06-15). "Effects of 8-hour time restricted feeding on body weight and metabolic disease risk factors in obese adults: A pilot study". Nutrition and Healthy Aging. 4 (4): 345–353. doi:10.3233/NHA-170036. PMC 6004924. PMID 29951594.
  26. Gabel, Kelsey; Hoddy, Kristin K.; Varady, Krista A. (January 2019). "Safety of 8-h time restricted feeding in adults with obesity". Applied Physiology, Nutrition, and Metabolism. 44 (1): 107–109. doi:10.1139/apnm-2018-0389. hdl:1807/92910. ISSN 1715-5312. PMID 30216730. S2CID 207086351.
  27. Patikorn, Chanthawat; Roubal, Kiera; Veettil, Sajesh K.; Chandran, Viji; Pham, Tuan; Lee, Yeong Yeh; Giovannucci, Edward L.; Varady, Krista A.; Chaiyakunapruk, Nathorn (2021-12-17). "Intermittent Fasting and Obesity-Related Health Outcomes: An Umbrella Review of Meta-analyses of Randomized Clinical Trials". JAMA Network Open. 4 (12): e2139558. doi:10.1001/jamanetworkopen.2021.39558. ISSN 2574-3805. PMC 8683964. PMID 34919135.
  28. Varady, Krista A.; Cienfuegos, Sofia; Ezpeleta, Mark; Gabel, Kelsey (2022-02-22). "Clinical application of intermittent fasting for weight loss: progress and future directions". Nature Reviews Endocrinology. doi:10.1038/s41574-022-00638-x. ISSN 1759-5029. PMID 35194176. S2CID 247014404.
  29. Varady, Krista A.; Cienfuegos, Sofia; Ezpeleta, Mark; Gabel, Kelsey (2021-10-11). "Cardiometabolic Benefits of Intermittent Fasting". Annual Review of Nutrition. 41 (1): 333–361. doi:10.1146/annurev-nutr-052020-041327. ISSN 0199-9885. PMID 34633860. S2CID 238636406.
  30. McStay, Mara; Gabel, Kelsey; Cienfuegos, Sofia; Ezpeleta, Mark; Lin, Shuhao; Varady, Krista A. (2021-10-01). "Intermittent Fasting and Sleep: A Review of Human Trials". Nutrients. 13 (10): 3489. doi:10.3390/nu13103489. ISSN 2072-6643. PMC 8539054. PMID 34684490.
  31. "Krista Varady receives 2017 Mead Johnson Award". ahs.uic.edu. Retrieved 2022-03-29.
  32. American Society for Nutrition (2022-03-28). "American Society for Nutrition Awards Prior Recipients" (PDF). Retrieved 2022-03-28.
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