Inosine pranobex
Inosine pranobex (BAN; also known as inosine acedoben dimepranol (INN) or methisoprinol) is an antiviral drug that is a combination of inosine and dimepranol acedoben (a salt of acetamidobenzoic acid and dimethylaminoisopropanol) in a ratio of 1 to 3. Inosine pranobex has no effect on viral particles itself. Instead, it acts as an immunostimulant, an analog of thymus hormones.[1] It is most commonly used to treat the rare measles complication subacute sclerosing panencephalitis in conjunction with intrathecal interferon-alpha therapy.[2]
 Chemical structures of the three components of inosine pranobex (from top to bottom: inosine, acedoben and dimethylamino isopropanol) | |
| Combination of | |
|---|---|
| Inosine | Immunostimulant |
| Dimethylaminoisopropanol | Immunostimulant |
| Acedoben | Immunostimulant |
| Clinical data | |
| Trade names | Imunovir, Delimmun, Isoprinosine, Viruxan |
| Other names | Methisoprinol |
| AHFS/Drugs.com | https://www.drugs.com/international/isoprinosine-500mg.html |
| Routes of administration | Oral |
| ATC code | |
| Legal status | |
| Legal status |
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| Identifiers | |
| PubChem CID | |
| ChemSpider | |
| KEGG | |
| ECHA InfoCard | 100.048.313 |
In the UK, inosine pranobex is also indicated for mucocutaneous infections due to herpes simplex virus (type 1 and type 2) and for treatment of genital warts as adjunctive therapy to podophyllotoxin or carbon dioxide laser.[3]
References
- American Cancer Society. "Inosine Pranobex". Archived from the original on 23 August 2010. Retrieved 31 July 2013.
- Campoli-Richards DM, Sorkin EM, Heel RC (Nov 1986). "Inosine pranobex. A preliminary review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy". Drugs. 32 (5): 383–424. doi:10.2165/00003495-198632050-00001. PMID 2431857. S2CID 46975349.
- "Imunovir 500mg Tablets". UK Electronic Medicines Compendium.