3-hydroxyisobutyryl-CoA hydrolase
In enzymology, a 3-hydroxyisobutyryl-CoA hydrolase (EC 3.1.2.4) is an enzyme that catalyzes the chemical reaction
- 3-hydroxy-2-methylpropanoyl-CoA + H2O CoA + 3-hydroxy-2-methylpropanoate
| 3-hydroxyisobutyryl-CoA hydrolase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 3-hydroxyisobutyryl-CoA hydrolase monomer, Human | |||||||||
| Identifiers | |||||||||
| EC no. | 3.1.2.4 | ||||||||
| CAS no. | 9025-88-1 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are 3-hydroxy-2-methylpropanoyl-CoA and H2O, whereas its two products are CoA and 3-hydroxy-2-methylpropanoate.
This enzyme belongs to the family of hydrolases, specifically those acting on thioester bonds. The systematic name of this enzyme class is 3-hydroxy-2-methylpropanoyl-CoA hydrolase. Other names in common use include 3-hydroxy-isobutyryl CoA hydrolase, and HIB CoA deacylase. This enzyme participates in 3 metabolic pathways: valine, leucine and isoleucine degradation, beta-alanine metabolism, and propanoate metabolism. 3-hydroxyisobutyryl-CoA hydrolase is encoded by HIBCH gene.[1]
References
- "OMIM Entry - * 610690 - 3-HYDROXYISOBUTYRYL-CoA HYDROLASE; HIBCH". www.omim.org. Retrieved 2017-11-20.
- Rendina G, Coon MJ (March 1957). "Enzymatic hydrolysis of the coenzyme a thiol esters of beta-hydroxypropionic and beta-hydroxyisobutyric acids". The Journal of Biological Chemistry. 225 (1): 523–34. PMID 13457352.