DKK4

DKK4
Identifiers
Aliases	DKK4, DKK-4, dickkopf WNT signaling pathway inhibitor 4
External IDs	OMIM: 605417 MGI: 2385299 HomoloGene: 8680 GeneCards: DKK4
Gene location (Human)
Chr.	Chromosome 8 (human)[1]
End	42,377,229 bp[1]
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)[2]
End	23,117,563 bp[2]
RNA expression pattern
	Top expressed in
	quadriceps femoris muscle; ; amygdala; ; pituitary gland; ; prostate; ; vastus lateralis muscle; ; cerebral cortex; ; cerebellar hemisphere; ; cerebellum;
	More reference expression data
	n/a
Gene ontology
Molecular function	molecular function; co-receptor binding; receptor antagonist activity;
Cellular component	extracellular region; cellular component; extracellular space;
Biological process	multicellular organism development; negative regulation of Wnt signaling pathway; Wnt signaling pathway; negative regulation of canonical Wnt signaling pathway; negative regulation of hair follicle placode formation; extracellular negative regulation of signal transduction; negative regulation of signaling receptor activity;
	Sources:Amigo / QuickGO
Orthologs
	27121
	234130
	ENSG00000104371
	ENSMUSG00000031535
	Q9UBT3
	Q8VEJ3
	NM_014420
	NM_145592
	NP_055235
	NP_663567
	Wikidata
View/Edit Human	View/Edit Mouse

Dickkopf-related protein 4 is a protein in the Dickkopf family that in humans is encoded by the DKK4 gene.[5]

In 2021, it was discovered by researchers at the Stanford University School of Medicine, that the gene is responsible for patterns on cats.[6]

References

GRCh38: Ensembl release 89: ENSG00000104371 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000031535 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Krupnik VE, Sharp JD, Jiang C, Robison K, Chickering TW, Amaravadi L, et al. (October 1999). "Functional and structural diversity of the human Dickkopf gene family". Gene. 238 (2): 301–13. doi:10.1016/S0378-1119(99)00365-0. PMID 10570958.
Armitage, Hanae (7 September 2021). "Spots, stripes and blotches: Color patterns of cat fur tracked to a key gene". Stanford University School of Medicine. Retrieved 21 December 2021.

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