Casper Hoogenraad

Casper Hoogenraad is a Dutch Cell Biologist who specializes in Molecular Neuroscience. The focus of his research is the basic molecular and cellular mechanisms that regulate the development and function of the brain. As of January 2020, he serves as Vice President of Neuroscience at Genentech Research and Early Development.

Casper Hoogenraad
Casper C. Hoogenraad
Born (1973-01-31) January 31, 1973
NationalityDutch
CitizenshipThe Netherlands
Alma materUtrecht University
Known forMolecular Neuroscience
Scientific career
FieldsNeuroscience
InstitutionsErasmus University, Massachusetts Institute of Technology, Utrecht University, Genentech
Doctoral advisorFrank Grosveld, Chris De Zeeuw
Other academic advisorsMorgan Sheng
Websitehttps://www.gene.com/scientists/our-scientists/casper-hoogenraad

Biography and research

Casper Hoogenraad was born in 1973 in Delft and grew up in Gouda, in The Netherlands. He received his B.S. in Biochemistry and M.S. in Molecular Biology from Utrecht University, and his doctorate in Cell Biology from the Erasmus University Rotterdam..[1]. In 2002, Hoogenraad started his post-doctoral research at Massachusetts Institute of Technology (MIT) in Cambridge, USA. In 2005, he returned to the Netherlands and joined the faculty of the Erasmus University Medical Center in Rotterdam as Associate Professor in the Department of Neuroscience. In 2011 he joined Utrecht University as full Professor of Molecular Neuroscience, and served as Chair of Cell Biology, Neurobiology and Biophysics for 10 years.[2] He is Adjunct Professor in Department of Biochemistry and Biophysics at University of California San Francisco (UCSF) [3]

During his career, he discovered molecular mechanisms and cell biological processes that control cytoskeleton remodeling and cargo trafficking during the development and function of the brain.

Most cited publications

  • Sheng M, Hoogenraad CC. The postsynaptic architecture of excitatory synapses: a more quantitative view. Annu. Rev. Biochem.. 2007 Jul 7;76:823-47. open access (According to Google Scholar, cited 824 times. [4])
  • "Visualization of microtubule growth in cultured neurons via the use of EB3-GFP (end-binding protein 3-green fluorescent protein)." Journal of Neuroscience 23.7 (2003): 2655-2664. open access ' (According to Google Scholar, cited 824 times. [4])
  • Jaworski J, Kapitein LC, Gouveia SM, Dortland BR, Wulf PS, Grigoriev I, Camera P, Spangler SA, Di Stefano P, Demmers J, Krugers H. Dynamic microtubules regulate dendritic spine morphology and synaptic plasticity. Neuron open access 2009 Jan 15;61(1):85-100. (According to Google Scholar, cited 617 times. [4])

Industrial career

Hoogenraad was recruited to Genentech, a member of the Roche Group, as Senior Fellow and head of Neuroscience.[5] As of January 2020, he is Vice President of Neuroscience at Genentech Research and Early Development.[6]

Honors

He is an elected member of the European Molecular Biology Organization[7] and the Editorial Board of Neuron[8]

In 2016 he became the 10th recipient of the IBRO-Kemali International Prize, in the field of basic and clinical Neuroscience[9]

Science outreach

In 2013, his laboratory made an animation movie, named 'A Day in the Life of a Motor Protein', which has received >1 million views on youtube.[10] During this short five-minute movie, we follow John, a motor protein, who has to transport a large package through the narrow streets in the city of Utrecht, illustrating the importance and challenges of intracellular transport.

References

  1. "PhD thesis". EUR, Erasmus University Rotterdam.
  2. "Cell Biology lab". UU, Utrecht University.
  3. "UCSF lab".
  4. Google Scholar author page, accessed March 14, 2022
  5. "ASCB profile". ASCB Press - Mary Spiro.
  6. "Genentech lab". Genentech, member of the Roche group.
  7. "EMBO member". EMBO Press. Archived from the original on 2015-12-01.
  8. "Editorial Board: Neuron". Cell Press.
  9. "IBRO Kemali Prize". IBRO, IBRO, the International Brain Research Organization. Archived from the original on 2015-09-05.
  10. A Day in the Life of a Motor Protein (Youtube). REDRUM, Ede, The Netherlands.
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