Caprin-1

CAPRIN1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4WBE, 4WBP
Identifiers
Aliases	CAPRIN1, GPIAP1, GPIP137, GRIP137, M11S1, RNG105, p137GPI, cell cycle associated protein 1
External IDs	OMIM: 601178 MGI: 1858234 HomoloGene: 4310 GeneCards: CAPRIN1
Gene location (Human)
Chr.	Chromosome 11 (human)[1]
End	34,102,610 bp[1]
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)[2]
End	103,627,994 bp[2]
RNA expression pattern
	Top expressed in
	testicle; ; lung; ; kidney; ; heart; ; stomach; ; endometrium;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	GO:0001948 protein binding; RNA binding;
Cellular component	cytoplasmic stress granule; dendrite; P-body; integral component of plasma membrane; cell projection; membrane; cytoplasm; cytosol; synapse;
Biological process	cell differentiation; negative regulation of translation; positive regulation of dendrite morphogenesis; positive regulation of dendritic spine morphogenesis;
	Sources:Amigo / QuickGO
Orthologs
	4076
	53872
	ENSG00000135387
	ENSMUSG00000027184
	Q14444
	Q60865
	NM_005898; NM_203364
	NM_001111289; NM_001111290; NM_001111291; NM_001111292; NM_016739
	NP_005889; NP_976240
	NP_001104759; NP_001104760; NP_001104761; NP_001104762; NP_058019
	Wikidata
View/Edit Human	View/Edit Mouse

Caprin-1 is a protein that in humans is encoded by the CAPRIN1 gene.[5][6][7][8][9][10] It is suggested that Caprin1 (a.k.a. RNG105) is essential for the formation of long-term memory.[11]

References

GRCh38: Ensembl release 89: ENSG00000135387 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000027184 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Ellis JA, Luzio JP (September 1995). "Identification and characterization of a novel protein (p137) which transcytoses bidirectionally in Caco-2 cells". The Journal of Biological Chemistry. 270 (35): 20717–23. doi:10.1074/jbc.270.35.20717. PMID 7657653.
Wang B, David MD, Schrader JW (October 2005). "Absence of caprin-1 results in defects in cellular proliferation". Journal of Immunology. 175 (7): 4274–82. doi:10.4049/jimmunol.175.7.4274. PMID 16177067.
Solomon S, Xu Y, Wang B, David MD, Schubert P, Kennedy D, Schrader JW (March 2007). "Distinct structural features of caprin-1 mediate its interaction with G3BP-1 and its induction of phosphorylation of eukaryotic translation initiation factor 2alpha, entry to cytoplasmic stress granules, and selective interaction with a subset of mRNAs". Molecular and Cellular Biology. 27 (6): 2324–42. doi:10.1128/MCB.02300-06. PMC 1820512. PMID 17210633.
Grill B, Wilson GM, Zhang KX, Wang B, Doyonnas R, Quadroni M, Schrader JW (February 2004). "Activation/division of lymphocytes results in increased levels of cytoplasmic activation/proliferation-associated protein-1: prototype of a new family of proteins". Journal of Immunology. 172 (4): 2389–400. doi:10.4049/jimmunol.172.4.2389. PMID 14764709.
Katsafanas GC, Moss B (December 2004). "Vaccinia virus intermediate stage transcription is complemented by Ras-GTPase-activating protein SH3 domain-binding protein (G3BP) and cytoplasmic activation/proliferation-associated protein (p137) individually or as a heterodimer". The Journal of Biological Chemistry. 279 (50): 52210–7. doi:10.1074/jbc.M411033200. PMID 15471883.
"Entrez Gene: GPIAP1 GPI-anchored membrane protein 1".
Nakayama K, Ohashi R, Shinoda Y, Yamazaki M, Abe M, Fujikawa A, et al. (November 2017). "RNG105/caprin1, an RNA granule protein for dendritic mRNA localization, is essential for long-term memory formation". eLife. 6. doi:10.7554/eLife.29677. PMC 5697933. PMID 29157358.

Gessler M, Klamt B, Tsaoussidou S, Ellis JA, Luzio JP (February 1996). "The gene encoding the GPI-anchored membrane protein p137GPI (M11S1) maps to human chromosome 11p13 and is highly conserved in the mouse". Genomics. 32 (1): 169–70. doi:10.1006/geno.1996.0099. PMID 8786113.
de Vries H, Rüegsegger U, Hübner W, Friedlein A, Langen H, Keller W (November 2000). "Human pre-mRNA cleavage factor II(m) contains homologs of yeast proteins and bridges two other cleavage factors". The EMBO Journal. 19 (21): 5895–904. doi:10.1093/emboj/19.21.5895. PMC 305781. PMID 11060040.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000135387 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000027184 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7657653-5] Ellis JA, Luzio JP (September 1995). "Identification and characterization of a novel protein (p137) which transcytoses bidirectionally in Caco-2 cells". The Journal of Biological Chemistry. 270 (35): 20717–23. doi:10.1074/jbc.270.35.20717. PMID 7657653.

[pmid16177067-6] Wang B, David MD, Schrader JW (October 2005). "Absence of caprin-1 results in defects in cellular proliferation". Journal of Immunology. 175 (7): 4274–82. doi:10.4049/jimmunol.175.7.4274. PMID 16177067.

[pmid17210633-7] Solomon S, Xu Y, Wang B, David MD, Schubert P, Kennedy D, Schrader JW (March 2007). "Distinct structural features of caprin-1 mediate its interaction with G3BP-1 and its induction of phosphorylation of eukaryotic translation initiation factor 2alpha, entry to cytoplasmic stress granules, and selective interaction with a subset of mRNAs". Molecular and Cellular Biology. 27 (6): 2324–42. doi:10.1128/MCB.02300-06. PMC 1820512. PMID 17210633.

[pmid14764709-8] Grill B, Wilson GM, Zhang KX, Wang B, Doyonnas R, Quadroni M, Schrader JW (February 2004). "Activation/division of lymphocytes results in increased levels of cytoplasmic activation/proliferation-associated protein-1: prototype of a new family of proteins". Journal of Immunology. 172 (4): 2389–400. doi:10.4049/jimmunol.172.4.2389. PMID 14764709.

[pmid15471883-9] Katsafanas GC, Moss B (December 2004). "Vaccinia virus intermediate stage transcription is complemented by Ras-GTPase-activating protein SH3 domain-binding protein (G3BP) and cytoplasmic activation/proliferation-associated protein (p137) individually or as a heterodimer". The Journal of Biological Chemistry. 279 (50): 52210–7. doi:10.1074/jbc.M411033200. PMID 15471883.

[entrez-10] "Entrez Gene: GPIAP1 GPI-anchored membrane protein 1".

[11] Nakayama K, Ohashi R, Shinoda Y, Yamazaki M, Abe M, Fujikawa A, et al. (November 2017). "RNG105/caprin1, an RNA granule protein for dendritic mRNA localization, is essential for long-term memory formation". eLife. 6. doi:10.7554/eLife.29677. PMC 5697933. PMID 29157358.

Caprin-1

References

Further reading