CIC (gene)

CIC
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2M41, 4J2J, 4J2L
Identifiers
Aliases	CIC, capicua transcriptional repressor, MRD45, CIC gene
External IDs	OMIM: 612082 MGI: 1918972 HomoloGene: 87637 GeneCards: CIC
Gene location (Human)
Chr.	Chromosome 19 (human)[1]
End	42,295,797 bp[1]
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)[2]
End	24,993,584 bp[2]
RNA expression pattern
	Top expressed in
	cerebellar hemisphere; ; cerebellum; ; sural nerve;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; GO:0001948 protein binding; chromatin binding; GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleus; nucleoplasm; intracellular membrane-bounded organelle; protein-containing complex;
Biological process	transcription, DNA-templated; regulation of transcription, DNA-templated; negative regulation of transcription by RNA polymerase II; brain development; learning; memory; social behavior; negative regulation of transcription, DNA-templated; lung alveolus development;
	Sources:Amigo / QuickGO
Orthologs
	23152
	71722
	ENSG00000079432
	ENSMUSG00000005442
	Q96RK0
	Q924A2
NM_001304815; NM_015125; NM_001379480; NM_001379482; NM_001379484;
	NM_001379485; NM_001386298
	NM_001110131; NM_001110132; NM_027882; NM_001302811
NP_001291744; NP_055940; NP_001366409; NP_001366411; NP_001366413;
	NP_001366414
	NP_001289740; NP_082158
	Wikidata
View/Edit Human	View/Edit Mouse

Protein capicua homolog is a protein that in humans is encoded by the CIC gene.[5][6][7]

The term capicua derives from the Catalan expression cap-i-cua which literally translates to "head-and-tail".[8].

Clinical Significance

CIC gene deletion forms part of the 1p/19q codeletion mutation seen in oligodendroglioma, a form of primary brain tumour.[9] FUBP1 gene is also lost in the 1p/19q codeletion mutation.

GRCh38: Ensembl release 89: ENSG00000079432 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000005442 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Lee CJ, Chan WI, Cheung M, Cheng YC, Appleby VJ, Orme AT, Scotting PJ (Oct 2002). "CIC, a member of a novel subfamily of the HMG-box superfamily, is transiently expressed in developing granule neurons". Brain Res Mol Brain Res. 106 (1–2): 151–6. doi:10.1016/S0169-328X(02)00439-4. PMID 12393275.
Lee CJ, Chan WI, Scotting PJ (Jun 2005). "CIC, a gene involved in cerebellar development and ErbB signaling, is significantly expressed in medulloblastomas". J Neurooncol. 73 (2): 101–8. doi:10.1007/s11060-004-4598-2. PMID 15981098. S2CID 24938086.
"Entrez Gene: CIC capicua transcriptional repressor [ Homo sapiens (human) ]".
"Society for Developmental Biology". SDB Online. Retrieved 23 March 2022.
Weller, Michael (8 December 2020). "EANO guidelines on the diagnosis and treatment of diffuse gliomas of adulthood". Nature Reviews, Clinical Oncology. 18: 170–186. doi:10.1038/s41571-020-00447-z.

Human CIC genome location and CIC gene details page in the UCSC Genome Browser.

Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.
Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell. Proteomics. 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19". Nature. 428 (6982): 529–35. Bibcode:2004Natur.428..529G. doi:10.1038/nature02399. PMID 15057824.
Nagase T, Ishikawa K, Nakajima D, et al. (1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 4 (2): 141–50. doi:10.1093/dnares/4.2.141. PMID 9205841.

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