BPIFB4

BPIFB4
Identifiers
Aliases	BPIFB4, C20orf186, LPLUNC4, RY2G5, dJ726C3.5, BPI fold containing family B member 4
External IDs	OMIM: 615718 MGI: 2685852 HomoloGene: 66971 GeneCards: BPIFB4
Gene location (Human)
Chr.	Chromosome 20 (human)[1]
End	33,111,751 bp[1]
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)[2]
End	153,806,021 bp[2]
RNA expression pattern
	Top expressed in
	anterior pituitary; ; nasopharynx; ; sural nerve; ; pituitary gland; ; lymph node; ; stomach;
	More reference expression data
	n/a
Orthologs
	149954
	381399
	ENSG00000186191
	ENSMUSG00000074665
	P59827
	A2BGH0
	NM_182519
	NM_001034875
	NP_872325
	NP_001030047
	Wikidata
View/Edit Human	View/Edit Mouse

BPI fold containing family B, member 4 is a protein that in humans is encoded by the BPIFB4 gene.[5]

The study of many populations of centenarians made it possible to identify the longevity-associated variant (LAV) of the BPIFB4 gene.[6] The gene transfer induced forced expression of LAV-BPIFB4 both in old mice and in animal model of hypertension reduced blood pressure and rescued age-related endothelial dysfunction stimulating endothelial nitric oxide synthase activation.[6]

As a gene associated with exceptional longevity, capable to protect from hypertension, atherosclerosis, diabetic cardiopathy, frailty, and inflammaging, LAV-BPIFB4 gene is a promising candidate new ‘drug’ to treat atherosclerosis, its cardiovascular complications, and neurodegenerative diseases.[7]

References

GRCh38: Ensembl release 89: ENSG00000186191 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000074665 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: BPI fold containing family B, member 4".
Villa F, Carrizzo A, Spinelli CC, Ferrario A, Malovini A, Maciąg A, Puca AA (Jul 2015). "Genetic analysis reveals a longevity-associated protein modulating endothelial function and angiogenesis". Circulation Research. 117 (4): 333–345. doi:10.1161/CIRCRESAHA.117.305875. PMC 5496930. PMID 26034043.
Dossena M, Ferrario A, Lopardo V, Ciaglia E, Puca AA (September 2020). "New Insights for BPIFB4 in Cardiovascular Therapy". International Journal of Molecular Sciences. 21 (19): 7163. doi:10.3390/ijms21197163. PMC 7583974. PMID 32998388.

Bingle CD, Craven CJ (August 2003). "Comparative analysis of the PLUNC (palate, lung and nasal epithelium clone) protein families". Biochemical Society Transactions. 31 (Pt 4): 806–9. doi:10.1042/bst0310806. PMID 12887310.
Andrault JB, Gaillard I, Giorgi D, Rouquier S (August 2003). "Expansion of the BPI family by duplication on human chromosome 20: characterization of the RY gene cluster in 20q11.21 encoding olfactory transporters/antimicrobial-like peptides". Genomics. 82 (2): 172–84. doi:10.1016/S0888-7543(03)00102-2. PMID 12837268.
Bingle CD, Seal RL, Craven CJ (August 2011). "Systematic nomenclature for the PLUNC/PSP/BSP30/SMGB proteins as a subfamily of the BPI fold-containing superfamily". Biochemical Society Transactions. 39 (4): 977–83. doi:10.1042/BST0390977. PMC 3196848. PMID 21787333.
Bingle CD, Craven CJ (April 2002). "PLUNC: a novel family of candidate host defence proteins expressed in the upper airways and nasopharynx". Human Molecular Genetics. 11 (8): 937–43. doi:10.1093/hmg/11.8.937. PMID 11971875.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000186191 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000074665 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: BPI fold containing family B, member 4".

[Puca-6] Villa F, Carrizzo A, Spinelli CC, Ferrario A, Malovini A, Maciąg A, Puca AA (Jul 2015). "Genetic analysis reveals a longevity-associated protein modulating endothelial function and angiogenesis". Circulation Research. 117 (4): 333–345. doi:10.1161/CIRCRESAHA.117.305875. PMC 5496930. PMID 26034043.

[7] Dossena M, Ferrario A, Lopardo V, Ciaglia E, Puca AA (September 2020). "New Insights for BPIFB4 in Cardiovascular Therapy". International Journal of Molecular Sciences. 21 (19): 7163. doi:10.3390/ijms21197163. PMC 7583974. PMID 32998388.

BPIFB4

References

Further reading