Aglycone

An aglycone (aglycon[1] or genin) is the compound remaining after the glycosyl group on a glycoside is replaced by a hydrogen atom.[2] For example, the aglycone of a cardiac glycoside would be a steroid molecule.

Research

A way to identify aglycone is proposed to extract it from Agave spp. by using H-NMR and Heteronuclear multiple bond correlation (HMBC) experiments. The HMBC experiment can be combined with other techniques such as mass spectrometry to further examine the structure and the function of aglycone.[3]

Samples of glycones and glycosides from limonoids can be simultaneously quantified through a high performance liquid chromatography method (HPLC) where a binary solvent system and a diode array detector separate and detect them at a sensitivity of 0.25-0.50 µg.[4]

A study on molecular markers in human aortic endothelial cells published that aglycone stopped cell migration but not monocyte adhesion, which is the initial step of atherosclerotic plaque formation.[5]

See also

References
  1. "2-Carb-33". www.chem.qmul.ac.uk. Archived from the original on 12 November 2016. Retrieved 21 April 2018.
  2. IUPAC Compendium of Chemical Terminology 2nd Edition (1997) 1995, 67, 1312
  3. Simonet, Ana (2021), "Features in the NMR spectra of the aglycones of Agave spp. saponins. HMBC method for aglycone identification (HMAI)", Phytochemical Analysis : Pca, 32 (1): 38–61, doi:10.1002/pca.2946, PMID 32515107, S2CID 219549980
  4. Vikram, Amit; Jayaprakasha, G. K.; Patil, Bhimanagouda S. (2007-05-08). "Simultaneous determination of citrus limonoid aglycones and glucosides by high performance liquid chromatography". Analytica Chimica Acta. 590 (2): 180–186. doi:10.1016/j.aca.2007.03.029. ISSN 0003-2670.
  5. Giménez‐Bastida, Juan A., Ellagitannin metabolites, urolithin A glucuronide and its aglycone urolithin A, ameliorate TNF‐α‐induced inflammation and associated molecular markers in human aortic endothelial cells, vol. 56, pp. 784–796


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