Aap Ke Aa Jane Se

Set in Kanpur, 42-year-old Vedika Gupta is a simple and single mother, who faces many hardships and lives with her mother Manjula and 15-year-old daughter Arya Mathur. Sahil Agarwal, a 24-year-old irresponsible young man, returns to his home after his studies. His elder aunt Bimla fixes his wedding to his friend, Nidhi. However, Sahil eventually falls in love with Vedika who refuses to accept it due to their age gap and social problems. But soon she realizes her love and accepts Sahil. Due to a misunderstanding by Nidhi, Vedika thinks Sahil helped her to insult Arya.

Vedika teams with his cousin Yash to destroy the Agarwals. He proposes to her and they marry. Soon, Yash dies from cancer. Instead of him, Vedika gets pregnant with Sahil's child via IVF. Bimla poisons and kills Sahil's mother, Anjana. Believing Vedika as the culprit, Sahil has her jailed and marries her cousin Bhumi. Vedika delivers a son. Bimla replaces Vedika's son to a stillborn child who later replaces to her own daughter Gauri's daughter by her husband, Deepak. Vedika leaves the city; Bimla handovers Vedika's son to Sahil who adopts and names the baby as Ved, unaware that the child is his.

Vedika returns to Kanpur with her daughter, Sadika. Sahil lives with Bhumi and Ved. Arya returns to India after her studies. Vedika soon learns Sadika is Gauri and Deepak's daughter, and Ved is her real son. Later Sahil also learns he is his son and Anjana was killed by Bimla. Enraged, he leaves her and Bhumi; he unites with and marries Vedika who again gets pregnant with his child. She meets Sahil's look-alike, Jackie who turns out to be his twin brother. Arya falls in love with and marries Jackie's foster brother, Guddu.

Sahil mistakenly marries Pankti, the daughter of politician Tej Pratap Singh. Vedika delivers another son, Virat. Sahil divorces Pankti. Bimla's long-lost son, Kshitij comes to destroy Agarwals and kills Guddu. Arya remarries Kshitij for revenge. Later, he shoots Sahil and Vedika to death. The two fall down a cliff dies vowing they'll be reborn to complete their love story; Kshitij is arrested.

Vedika and Sahil are reborn. Reborn Vedika is a caring and kind-hearted divorcee. Reborn Sahil falls for her but is engaged to her sister Avantika. The two meet the now old Manjula, who reveals they're reborn. Sahil and Vedika marry. To separate them, Avantika teams up with Tanuj, Vedika's ex-husband. He kidnaps her who kills him. Avantika is exposed and arrested. Sahil and Vedika remarry and unite forever.

• Suhasi Dhami as Vedika Mathur/Agarwal (née Gupta): Manjula's daughter; Rohit's sister; Bhumi's cousin; Yash and Anurag's former wife; Sahil's wife; Arya, Ved and Virat's mother; Sadika's foster mother (2018–2019)
• Karan Jotwani as Sahil Agarwal: Rishabh and Anjana's son; Jackie and Shruti's brother; Yash, Gauri, Prachi and Kshitij's cousin; Nidhi, Bhumi and Pankti's former husband; Vedika's husband; Arya's stepfather; Ved and Virat's father (2018–2019) / Jackie Srivastav: Rishabh and Anjana's son; Sahil and Shruti's brother; Yash, Gauri, Prachi and Kshitij's cousin; Usha's adopted son; Guddu and Mandakini's foster brother (2018–2019)
• Hetal Gada as Arya Tiwari/Srivastav/Agarwal (née Mathur): Anurag and Vedika's daughter; Sahil's step-daughter; Ved and Virat's half-sister; Puneesh, Guddu and Kshitij's former wife (2018–2019)
• Geeta Tyagi as Bimla Agarwal (née Devi) a.k.a Badi Amma): Ishwar's wife; Gauri, Prachi and Kshitij's mother; Yash's stepmother (2018–2019)
• Aekam Binjwe as Vedaansh "Ved" Agarwal: Sahil and Vedika's elder son; Bhumi's foster son; Virat's brother; Arya's half-brother; Sadika's cousin (2018–2019)
• Unknown as Virat Agarwal: Sahil and Vedika's younger son; Ved's brother; Arya's half-brother; Sadika's cousin (2019)
• Richa Bhattacharya as Manjula Gupta: Vedika and Rohit's mother; Arya, Ved and Virat's grandmother (2018–2019)
• Barsha Chatterjee as Maya Awasthi: Vedika's best friend; Raghav's wife (2018–2019)
• Manish Goplani as Ghoonghru a.k.a Kshitij "Krish" Agarwal: Ishwar and Bimla's son; Gauri and Prachi's brother; Yash's half-brother; Arya's former husband (2019)
• Ashish Dixit as Ishaan "Guddu" Srivastava: Usha's son; Mandakini's brother; Jackie's foster brother; Arya's former husband (2018–2019)
• Deepali Saini as Mandakini Srivastava: Usha's daughter; Guddu's sister; Jackie's foster sister (2018–2019)
• Alice Kaushik as Daisy: Jackie's girlfriend (2018)
• Ekta Sharma as Usha Srivastava: Guddu and Mandakini's mother; Jackie's foster mother (2018–2019)
• Resha Konkar as Gauri Ramnani/Pathak (née Agarwal): Ishwar and Bimla's younger daughter; Sahil, Jackie and Shruti's cousin; Prachi and Kshitij's sister; Yash's half-sister; Deepak and Manish's former wife; Sadika's mother (2018–2019)
• Sailesh Gulabani as Deepak Ramnani – Gauri's former husband; Shruti's husband; Sadika's father. (2018–2019)
• Hannah Chaudhary as Sadika Ramnani – Gauri and Deepak's daughter; Vedika's foster daughter. (2018)
• Kshitija Saxena as Shruti Agarwal Ramnani – Rishab and Anjana's daughter; Sahil and Jackie's sister; Karan's former wife; Deepak's wife. (2018–2019)
• Nidhi Mathur as Prachi Agarwal Tiwari – Ishwar and Bimla's elder daughter; Gauri and Kshitij's sister; Yash's half-sister; Puneesh's wife. (2018–2019)
• Karan Mehat as Puneesh Tiwari – Tushar's uncle; Prachi's husband. (2018–2019)
• Jannat Zubair Rahmani as Pankti Singh – Tej Pratap and Sadhna's daughter; Sahil's former wife. (2019)
• Amit Behl as Politician Tej Pratap Singh – Sadhna's husband; Pankti's father. (2019)
• Neetu Pandey as Sadhna Singh – Tej Pratap's wife; Pankti's mother. (2019)
• Amit Bhanushali as Karan Verma – Sahil's best friend; Shruti's former husband. (2018)
• Priyanka Purohit as Bhumi Agarwal – Manjula's niece; Vedika and Rohit's cousin; Sahil's former wife; Ved's foster mother. (2018–2019)
• Abhiroy Singh as Yash Agarwal – Ishwar and Leela's son; Gauri, Prachi and Kshitij's half-brother; Vedika's late husband. (2018) (Dead)
• Rudrakshi Gupta as Anjana Mehrotra Agarwal – Rishab's wife; Sahil, Jackie and Shruti's mother. (2018) (Dead)
• Mehul Bhojak as Manish Mehta – Gauri's former husband. (2018)
• Ravish Dumra as Tushar – Puneesh's cousin son; Arya's friend. (2018)
• Priyal Gor as Chameli / Fake Vedika – A woman who pretend as Vedika after her missing. (2018)
• Shaily Pandey / Jazz Sodhi as Nidhi Tripathi – Sunanda's daughter; Mohit's sister; Sahil's childhood friend and former fiancée. (2018)
• Nidhi Vikram as Sunanda Tripathi – Nidhi and Mohit's mother. (2018)
• Varun Tiwari as Mohit Tripathi – Sunanda's son; Nidhi's brother. (2018)
• Shantanu Monga as Rohit Gupta – Manjula's son; Vedika's brother; Kiran's husband. (2018)
• Iti Kaurav as Kiran Gupta – Rohit's wife. (2018)
• Unknown as Anurag Mathur – Sunil's brother; Vedika's late husband; Arya's father (2018) (Dead)
• Rudra Kaushik as Sunil Mathur – Anurag's brother; Arya's uncle. (2018)
• Mohit Daga as Gautam – Vedika's boss. (2018)

• Suhasi Dhami as Vedika Malhotra/Kashyap (née Pratab): Prem and Prabha's daughter; Avantika's sister; Tanuj and Sahil's wife (2019)
• Karan Jotwani as Sahil Kashyap: Shashi and Rekha's son; Geet's brother; Vedika's husband (2019)
• Richa Bhattacharya as Manjula Gupta: She reprised her role of Season 1 as First Vedika's mother (2018–2019)
• Micckie Dudaaney as Tanuj Malhotra – Reborn Vedika's former husband. (2019) (Dead)
• Manisha Rawat as Avantika Pratab – Prem and Prabha's daughter; Reborn Vedika's sister; Reborn Sahil's former fiancée. (2019)
• Harish Chhabra as Prem Pratab – Chetna's brother; Prabha's husband; Avantika and reborn Vedika's father. (2019)
• Hetal Yadav as Prabha Somani Pratab – Prem's wife; Avantika and reborn Vedika's mother. (2019)
• Simran Gangwani as Chetna Pratab – Prem's sister. (2019)
• Yajuvendra Singh as Shashi Kashyap – Dheeraj's brother; Rekha's husband; Geet and reborn Sahil's father. (2019)
• Zahida Parveen as Rekha Singh Kashyap – Shashi's wife; Geet and reborn Sahil's mother. (2019)
• Sonali Jha as Geet Kashyap – Shashi and Rekha's daughter; Reborn Sahil's sister. (2019)
• Vishnu Sharma as Dheeraj Kashyap – Shashi's brother; Meena's husband. (2019)
• Leena Acharya as Meena Soni Kashyap – Dheeraj's wife. (2019)
• Mitali Pandey as Sakshi – Reborn Vedika's friend. (2019)

• Ravi Dubey and Nia Sharma from Jamai Raja[7] (2018)
• Shraddha Arya as Preeta from Kundali Bhagya (2018)
• Neelam Mehra from Kundali Bhagya (2018)