AFSC
AFSC may stand for any of the following:
- Affiliate of the Institute of the Brothers of the Christian Schools, used as post-nominal initials
- American Friends Service Committee
- Air Force Specialty Code
- Air Force Systems Command
- Air Force Space Command, often abbreviated as AFSPC to avoid confusion with the now defunct AF Systems Command
- Air Force School, Coimbatore, a school run by Indian Air Force
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