5-Methyluridine

The chemical compound 5-methyluridine (symbol m⁵U or m5U), also called ribothymidine, is a pyrimidine nucleoside. It is the ribonucleoside counterpart to the deoxyribonucleoside thymidine, which lacks a hydroxyl group at the 2' position. 5-Methyluridine contains a thymine base joined to a ribose pentose sugar.[3] It is a white solid.

Not to be confused with uridine, thymidine, or thymine.
5-Methyluridine
Names
IUPAC name
5-Methyluridine
Preferred IUPAC name
1-[(2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4(1H,3H)-dione
Other names
Ribothymidine, Ribosylthymine; Thymine riboside, m5U
Identifiers
3D model (JSmol)
ChemSpider
ECHA InfoCard 100.014.522
UNII
  • InChI=1S/C10H14N2O6/c1-4-2-12(10(17)11-8(4)16)9-7(15)6(14)5(3-13)18-9/h2,5-7,9,13-15H,3H2,1H3,(H,11,16,17)/t5-,6-,7-,9-/m1/s1 N
    Key: DWRXFEITVBNRMK-JXOAFFINSA-N N
  • InChI=1/C10H14N2O6/c1-4-2-12(10(17)11-8(4)16)9-7(15)6(14)5(3-13)18-9/h2,5-7,9,13-15H,3H2,1H3,(H,11,16,17)/t5-,6-,7-,9-/m1/s1
    Key: DWRXFEITVBNRMK-JXOAFFINBW
  • CC1=CN(C(=O)NC1=O)[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O
Properties
C10H14N2O6
Molar mass 258.23 g/mol
Density 1,6 g/cm3[1]
Melting point 184[2] °C (363 °F; 457 K)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
N verify (what is YN ?)
Infobox references

See also

References
  1. "5-Methyluridine". ChemSpider. Retrieved December 6, 2018.
  2. William M. Haynes (2016). CRC Handbook of Chemistry and Physics (97th ed.). Boca Raton: CRC Press. p. 3-400. ISBN 978-1-4987-5429-3.
  3. Shobbir Hussain (2019). "Catalytic crosslinking-based methods for enzyme-specified profiling of RNAribonucleotide modifications". Methods. 156: 60-65. doi:10.1016/j.ymeth.2018.10.003.
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.